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Calcium channel blockers, also known as calcium channel antagonists, are widely used for a number of health conditions. [8] Thus they are commonly present in many people's homes. In young children one pill may cause serious health problems and potentially death. [8]
The most common cause for hypocalcemia is iatrogenic hypoparathyroidism. [2] Other causes include other forms of hypoparathyroidism, vitamin D deficiency, kidney failure, pancreatitis, calcium channel blocker overdose, rhabdomyolysis, tumor lysis syndrome, and medications such as bisphosphonates or denosumab. [1]
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists [2] are a group of medications that disrupt the movement of calcium (Ca 2+) through calcium channels. [3] Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension.
Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body. In a healthy physiology, extracellular calcium levels are maintained within a tight range through the actions of parathyroid hormone , vitamin D and the calcium ...
P-type calcium channel ("Purkinje") /Q-type calcium channel: HVA (high voltage activated) Ca v 2.1 : α 2 δ, β, possibly γ: Purkinje neurons in the cerebellum / Cerebellar granule cells: N-type calcium channel ("Neural"/"Non-L") HVA (high voltage activated) Ca v 2.2 : α 2 δ/β 1, β 3, β 4, possibly γ: Throughout the brain and peripheral ...
Studies have shown that the intrathecal injection of the calcium channel inhibitor ziconotide, to block the N-type calcium channels, have produced alleviation of intractable pain. [12] Blockade of the N-type calcium channel is a potential therapeutic strategy for the treatment of alcoholism. Because prolonged alcohol exposure over time has been ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Molecules that act as channel blockers are important in the field of pharmacology, as a large portion of drug design is the use of ion channel antagonists in regulating physiological response. The specificity of channel block molecules on certain channels makes it a valuable tool in the treatment of numerous disorders.