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Phenylglycine is the organic compound with the formula C 6 H 5 CH(NH 2)CO 2 H. It is a non-proteinogenic alpha amino acid related to alanine, but with a phenyl group in place of the methyl group. It is a white solid. The compound exhibits some biological activity. [1]
4-Hydroxyphenylglycine (HPG) is a non-proteogenic amino acid found in vancomycin and related glycopeptides. HPG is synthesized from the shikimic acid pathway and requires four enzymes to synthesize: [ 1 ] Both L - and D -HPG are used in the vancomycin class of antibiotics.
N-phenylsydnone was first prepared in 1935 by John Campbell Earl and Alan W. Mackney [Wikidata] by cyclodehydration of N-Nitroso-N-phenylglycine with acetic anhydride. [4] Later work showed that this could be applied fairly generally to the nitrosamines of N-substituted amino acids. [2]
[4] Medicinal chemists at Rhône-Poulenc worked in the preparation of semi-synthetic, water-soluble, derivatives of pristinamycin IA (B type streptogramin) and pristinamycin IIA (A type streptogramin) giving rise to quinupristin and dalfopristin , respectively, which, when administered in a 3:7 ratio, comprise the 1999 FDA approved drug Synercid .
The U.S. bond market will also be closed on Thursday and are scheduled to close at 2 p.m. ET on Friday, according to the Securities Industry and Financial Markets Association.
Cross-linking and immunoprecipitation (CLIP, or CLIP-seq) is a method used in molecular biology that combines UV crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding of post-transcriptional regulatory networks.
“Katabasis” by R.F. Kuang (Aug. 26) The author of “The Poppy War” and “Yellowface” returns with a dark academia fantasy described as Dante’s “Inferno” meets Susanna Clarke’s ...
Novo Nordisk said it expects results from a second Phase 3 trial of the medicine, this one in people with type 2 diabetes, in the first half of 2025. The study reported Friday, which Novo Nordisk ...