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Prolactin surges initiate the secretion of progesterone which maintains pregnancy and hence can initiate pseudopregnancy. The false maintenance of pregnancy exhibits the outward physical symptoms of pregnancy, in the absence of a foetus. [40] Prolactin receptor activation is essential for normal mammary gland development during puberty in mice ...
The magnitude that prolactin is elevated can be used as an indicator of the etiology of the hyperprolactinemia diagnosis. Prolactin levels over 250 ng/mL may suggest prolactinoma. Prolactin levels less than 100 ng/mL may suggest drug-induced hyperprolactinemia, macroprolactinemia, nonfunctioning pituitary adenomas, or systemic disorders.
Progesterone induces formation of tertiary side-branches in the mammary glands during puberty and during the luteal phase of the menstrual cycle upon which lobuloalveolar structures form under the influence of prolactin. Prolactin stimulates lactogenesis. [16] [17]
Galactorrhea hyperprolactinemia is increased blood prolactin levels associated with galactorrhea (abnormal milk secretion). It may be caused by such things as certain medications, pituitary disorders and thyroid disorders. The condition can occur in males as well as females.
Prolactin and insulin-like growth factor binding protein are two examples of the hormones and growth factors that relaxin can stimulate the secretion of. [21] Preprorelaxin is the collective term for the signal peptide , B chain, C peptide, and A chain found in the coding area of human relaxin genes. [ 22 ]
A prolactin cell (also known as a lactotropic cell, epsilon acidophil, lactotrope, lactotroph, mammatroph, mammotroph) is a cell in the anterior pituitary which produces prolactin (a peptide hormone) in response to hormonal signals including dopamine (which is inhibitory), thyrotropin-releasing hormone and estrogen (especially during pregnancy), which are stimulatory.
The initiation of pseudopregnancy is basically similar to the pregnancy regarding the activation of progestational state. The neuroendocrine pathway of pseudopregnancy in rats is mainly initiated by the nocturnal surge of prolactin. [13] The hormone prolactin produced regulates the activation and early maintenance of corpus luteum.
The most common complex found in blood consists of prolactin and immunoglobulin G (IgG). [1] While the free prolactin hormone is active, prolactin in the macroprolactin complex does not have any biological activity in the body and is considered benign. [2] However, macroprolactin is detected by all Laboratory tests that measure prolactin in ...