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  2. Ondansetron - Wikipedia

    en.wikipedia.org/wiki/Ondansetron

    Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...

  3. Antiemetic - Wikipedia

    en.wikipedia.org/wiki/Antiemetic

    5-HT 3 receptor antagonists block serotonin receptors in the central nervous system and gastrointestinal tract. As such, they can be used to treat post-operative and cytotoxic drug nausea & vomiting. However, they can also cause constipation or diarrhea, dry mouth, and fatigue. Dolasetron (Anzemet) can be administered in tablet form or in an ...

  4. 5-HT3 antagonist - Wikipedia

    en.wikipedia.org/wiki/5-HT3_antagonist

    The 5-HT 3 antagonists are also indicated in the prevention and treatment of radiation-induced nausea and vomiting (RINV), when needed, and postoperative nausea and vomiting (PONV). Although they are more effective at controlling CINV—where they stop symptoms altogether in up to 70% of people, and reduce them in the remaining 30%—, they are ...

  5. Serotonin receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Serotonin_receptor_antagonist

    Another subclass consists of drugs selectively acting at the 5-HT 3 receptors, and thus are known as 5-HT 3 antagonists. They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting. [1] They include, but are not limited to: Dolasetron; Granisetron; Ondansetron; Palonosetron; Tropisetron

  6. Aprepitant - Wikipedia

    en.wikipedia.org/wiki/Aprepitant

    Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. [5] It may be used together with ondansetron and dexamethasone. [5] It is taken by mouth [5] or administered by intravenous injection. [3]

  7. Drugs in pregnancy - Wikipedia

    en.wikipedia.org/wiki/Drugs_in_pregnancy

    First generation antihistamines have the ability to cross the blood-brain barrier which can result in sedative and anticholinergic effects while effectively treating allergic reactions and nausea and vomiting related to pregnancy. On the other hand, second generation antihistamines do not cross the blood-brain barrier, thus eliminating sedating ...

  8. Chemoreceptor trigger zone - Wikipedia

    en.wikipedia.org/wiki/Chemoreceptor_trigger_zone

    The neurotransmitters implicated in the control of nausea and vomiting include acetylcholine, dopamine, histamine (H1 receptor), substance P (NK-1 receptor), and serotonin (5-HT3 receptor). There are also opioid receptors present, which may be involved in the mechanism by which opiates cause nausea and vomiting.

  9. NK1 receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/NK1_receptor_antagonist

    NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK 1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy. [4] An example of a drug in this class is aprepitant.

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