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Methanol toxicity (also methanol poisoning) is poisoning from methanol, characteristically via ingestion. [1] Symptoms may include an altered/decreased level of consciousness, poor or no coordination, vomiting, abdominal pain, and a specific smell on the breath. [1] [2] Decreased vision may start as early as twelve hours after exposure. [2]
The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
Ethylene glycol has relatively high mammalian toxicity when ingested, roughly on par with methanol, with an oral LD Lo = 786 mg/kg for humans. [30] The major danger is due to its sweet taste , which can attract children and animals.
British backpacker and lawyer Simone White, 28, from Orpington in Kent was among those to have died from suspected methanol poisoning after allegedly being served free drinks in Laos‘s Vang ...
In October and November 2005, 34 people in Magadan died from methanol poisoning after drinking tainted liquor. [62] In December 2016, 72 people died in a mass methanol poisoning in Irkutsk, Siberia. The poisoning was precipitated by drinking counterfeit surrogate alcohol—actually scented bath lotion that was marked as not safe for consumption ...
Travellers are being warned of the dangers of methanol poisoning after six tourists to Laos have died. Methanol is an industrial chemical found in antifreeze and windshield washer fluid.
In 2012, around 50 people were killed in Cambodia after party-goers drank rice wine contaminated by methanol. Between 2018 to 2019, at least 40 people have died in Philippines after drinking palm ...