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Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
Provigil - used to treat excessive sleepiness and narcolepsy Prozac ( fluoxetine ) – an antidepressant of the SSRI class Luminal ( phenobarbital ) – a barbiturate with sedative and hypnotic properties
The following are settlements reached with US authorities against pharmaceutical companies to resolve allegations of "off-label" promotion of drugs. Under the Federal Food, Drug, and Cosmetic Act, it is illegal for pharmaceutical companies to promote their products for uses not approved by the Food and Drug Administration (FDA), and corporations that market drugs for off-label indications may ...
The pharmaceutical company Cephalon, the original United States market rights holder of modafinil, has demonstrated initiative in the development of a successor to the prototypical eugeroic. [25]
At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the (R)-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of (R)-(−)- and (S)-(−)- enantiomers
Provigil Nevirapine [citation needed] Norfloxacin [14] Oseltamivir [citation needed] Oxicams [7] Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam: Paracetamol [15] [16] Acetaminophen, Panadol, Tylenol Penicillins [5] Phenytoin [5] Rivoraxaban [17] Xarelto: Sitagliptin [citation needed] Sulfonamides [2] Tetracycline [2
The clinic also spent nearly $100,000 during that period on Provigil, a stimulant that is “55 times more expensive than the generic equivalent,” the report said.
Adrafinil, sold under the brand name Olmifon, is a wakefulness-promoting medication that was formerly used in France to improve alertness, attention, wakefulness, and mood, particularly in the elderly.
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