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These are characterized by a serum pH below 7.4 (acidosis) or above 7.4 (alkalosis), and whether the cause is from a metabolic process or respiratory process. If the body experiences one of these derangements, the body will try to compensate by inducing an opposite process (e.g. induced respiratory alkalosis for a primary metabolic acidosis). [7]
Lung compliance is an important measurement in respiratory physiology. [2] [3] Decreased pulmonary compliance may be associated with fibrosis. Increased pulmonary compliance may be associated with COPD and emphysema due to loss of alveolar and elastic tissue. Pulmonary surfactant increases compliance by decreasing the surface tension of water.
In general, compliance is defined by the change in volume (ΔV) versus the associated change in pressure (ΔP), or ΔV/ΔP: = During mechanical ventilation, compliance is influenced by three main physiologic factors:
The Shunt equation (also known as the Berggren equation) quantifies the extent to which venous blood bypasses oxygenation in the capillaries of the lung.. “Shunt” and “dead space“ are terms used to describe conditions where either blood flow or ventilation do not interact with each other in the lung, as they should for efficient gas exchange to take place.
Lung volumes. Functional residual capacity (FRC) is the volume of air present in the lungs at the end of passive expiration. [1] At FRC, the opposing elastic recoil forces of the lungs and chest wall are in equilibrium and there is no exertion by the diaphragm or other respiratory muscles.
Modes of mechanical ventilation are one of the most important aspects of the usage of mechanical ventilation.The mode refers to the method of inspiratory support. In general, mode selection is based on clinician familiarity and institutional preferences, since there is a paucity of evidence indicating that the mode affects clinical outcome.
The helium dilution technique is the way of measuring the functional residual capacity of the lungs (the volume left in the lungs after normal expiration).. This technique is a closed-circuit system where a spirometer is filled with a mixture of helium (He) and oxygen.
It is a marker of respiratory muscle function and strength. [28] Represented by centimeters of water pressure (cmH2O) and measured with a manometer . Maximum inspiratory pressure is an important and noninvasive index of diaphragm strength and an independent tool for diagnosing many illnesses. [ 29 ]