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However, the injury often takes weeks or months to heal, and the lung may be scarred. [2] Small pulmonary lacerations frequently heal by themselves if material is removed from the pleural space, but surgery may be required for larger lacerations that do not heal properly or that bleed. [21]
Lung surgery is a type of thoracic surgery involving the repair or removal of lung tissue, [1] and can be used to treat a variety of conditions ranging from lung cancer to pulmonary hypertension. Common operations include anatomic and nonanatomic resections, pleurodesis and lung transplants .
Lung cancer is the most diagnosed and deadliest cancer worldwide, with 2.2 million cases in 2020 resulting in 1.8 million deaths. [3] Lung cancer is rare in those younger than 40; the average age at diagnosis is 70 years, and the average age at death 72. [2] Incidence and outcomes vary widely across the world, depending on patterns of tobacco use.
Chemotherapy for NSCLC usually includes combination of two drugs (chemotherapy doublet), with one of the agents is cisplatin or carboplatin. In 2002, Schiller at al. published in the New England Journal of Medicine, a study that compared four chemotherapy regimens for advanced NSCLC, cisplatin and paclitaxel, cisplatin and gemcitabine, cisplatin and docetaxel, and carboplatin and paclitaxel. [14]
Pneumothorax occurs when there is air trapped between the lung and the chest wall; this can leave the patient's lung unable to fully inflate ("collapsed lung"). A bronchopleural fistula is when there is a tube-like opening that allows air to escape. [9] Minimally invasive surgery is beneficial for patient outcome, with reduced risk of ...
Anatomic lung resections require a dissection of the pulmonary hilum with individual ligation and division of the pulmonary artery, pulmonary vein, and the bronchus where these enter the lung. In the setting of lung cancer, the rationale for anatomic lung resection is a complete removal of a lung tumor along with the lymphatics that drain that ...
Nevertheless, this was a huge leap towards whole lung regeneration and transplants for humans, which has already taken another step forward with the lung regeneration of a non-human primate. [ 63 ] Cystic fibrosis is another disease of the lungs, which is highly fatal and genetically linked to a mutation in the CFTR gene .
After a pneumonectomy is performed, changes in the thoracic cavity occur to compensate for the altered anatomy. The remaining lung hyperinflates as well as shifting over along with the heart towards the now empty space. This space is full of air initially after surgery, but then it is absorbed, and fluid eventually takes its place. [9]
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