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  2. Ampicillin/sulbactam - Wikipedia

    en.wikipedia.org/wiki/Ampicillin/sulbactam

    Ampicillin-sulbactam only comes in a parenteral formulation to be either used as intravenous or intramuscular injections, and can be formulated for intravenous infusion. [2] [17] It is formulated in a 2:1 ratio of ampicillin:sulbactam. The commercial preparations available include: [17] 1.5 grams (1 gram ampicillin and 0.5 gram sulbactam)

  3. Sulbactam - Wikipedia

    en.wikipedia.org/wiki/Sulbactam

    Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. [6] Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.

  4. Sultamicillin - Wikipedia

    en.wikipedia.org/wiki/Sultamicillin

    The inclusion of sulbactam extends ampicillin's spectrum of action to beta-lactamase producing strains of bacteria. [2] Oral sulbactam with the intravenous form provides a regimen of continuous sulbactam therapy throughout the treatment, resulting in better clinical results. [citation needed] It was patented in 1979 and approved for medical use ...

  5. β-Lactamase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Β-Lactamase_inhibitor

    The Ambler classification system groups known beta-lactamase enzymes into four groups according to sequence homology and presumed phylogenetic relationships. Classes A, C and D cleave beta-lactams by a multi-step mechanism analogous to the mechanism of serine proteases. Upon binding, a serine hydroxyl group in the beta-lactamase active site ...

  6. Ampicillin - Wikipedia

    en.wikipedia.org/wiki/Ampicillin

    Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat several bacterial infections , such as respiratory tract infections , urinary tract infections , meningitis , salmonellosis , and endocarditis . [ 7 ]

  7. β-Lactam antibiotic - Wikipedia

    en.wikipedia.org/wiki/Β-Lactam_antibiotic

    This resistance mechanism underscores the importance of the structural integrity of the β-lactam ring for the antibiotic's function. [24] The color change from colorless or light yellow to amber or even red in an aqueous solution of a β-lactam antibiotic can denote β-lactamase hydrolysis of amide bonds in the β-lactam ring.

  8. Could Matt Gaetz decide to keep his House seat? It's ... - AOL

    www.aol.com/could-matt-gaetz-decide-keep...

    Ever since Matt Gaetz resigned from the House — and subsequently withdrew his name from co n sideration to be President-elect Donald Trump's nominee for attorney general — questions have ...

  9. Beta-lactamase - Wikipedia

    en.wikipedia.org/wiki/Beta-lactamase

    Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam—lactamase inhibitor combinations of amoxicillin-clavulanate (co-amoxiclav), ticarcillin-clavulanate (co-ticarclav), and ampicillin/sulbactam, they normally remain susceptible to ...