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Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.
A gene regulatory network [20] is a set of molecular regulators that interact with each other and with other substances in the cell. The regulator can be DNA, RNA, protein and complexes of these. Gene regulatory networks can be modeled in numerous ways including; Coupled ordinary differential equations, Boolean networks, Continuous networks ...
However, inferring the precise pairwise interactions of the gene regulatory network remains challenging due to the large number of functional genes and the inherent stochasticity of these systems. [ 1 ] [ 2 ] Despite these challenges, certain features of the gene regulatory network can still be extracted without fully inferring all the ...
Wagner's gene network model is a computational model of artificial gene networks, which explicitly modeled the developmental and evolutionary process of genetic regulatory networks. A population with multiple organisms can be created and evolved from generation to generation.
A biological network is a method of representing systems as complex sets of binary interactions or relations between various biological entities. [1] In general, networks or graphs are used to capture relationships between entities or objects. [1]
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
Creating a cellular model has been a particularly challenging task of systems biology and mathematical biology. It involves the use of computer simulations of the many cellular subsystems such as the networks of metabolites, enzymes which comprise metabolism and transcription, translation, regulation and induction of gene regulatory networks. [4]
Gene regulatory pathway. In genetics, a regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences ...