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Clobetasol propionate was patented in 1968 and came into medical use in 1978. [13] It is available as a generic medication . [ 10 ] In 2022, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate , has also been marketed, and is far more widely used in comparison. [ 2 ] [ 3 ]
[25] [26] However, since the correlation between long-term use of potent topical glucocorticoid in pregnant women and low birth weight cannot be neglected, pregnant women who require topical glucocorticoids should be administered with low- or medium-potency agents instead of potent or superpotent ones. If potent or superpotent topical ...
Long-term use of topical steroids can lead to secondary infection with fungus or bacteria (see tinea incognito), skin atrophy, telangiectasia (prominent blood vessels), skin bruising and fragility. [11] The use of the finger tip unit may be helpful in guiding how much topical steroid is required to cover different areas of the body.
Beclometasone dipropionate, an example of a widely used corticosteroid ester. Note the propionate groups at the C17α and C21α positions (top right corner). This is a list of corticosteroid esters, including esters of steroidal glucocorticoids and mineralocorticoids. [1] [2] [3]
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Treatment involves discontinuing the use of topical steroids, [2] either gradually or suddenly. [2] Counselling and cold compresses may also help. [ 2 ] Thousands of people congregate in online communities to support one another throughout the healing process, and cases have been reported in both adults and children.
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