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  2. Cataplexy - Wikipedia

    en.wikipedia.org/wiki/Cataplexy

    Cataplexy is the first symptom to appear in about 10% of cases of narcolepsy, [2] caused by an autoimmune destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition between wake and sleep states. [3]

  3. Narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Narcolepsy

    Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]

  4. Pediatric narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Pediatric_narcolepsy

    Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...

  5. Primary vs. secondary (i.e. comorbid) insomnia has been reunited into a single disorder: chronic insomnia. Narcolepsy has been divided into narcolepsy type 1 and narcolepsy type 2. These two types are distinguished by the presence or absence of cataplexy and the cerebrospinal fluid hypocretin-1 level.

  6. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  7. Night terror - Wikipedia

    en.wikipedia.org/wiki/Night_terror

    There have been no findings that show a cultural difference between manifestations of night terrors, though it is thought that the significance and cause of night terrors differ within cultures. Also, older children and adults provide highly detailed and descriptive images associated with their sleep terrors compared to younger children, who ...

  8. Sleep disorder - Wikipedia

    en.wikipedia.org/wiki/Sleep_disorder

    An estimated 17.3% of kids between 3 and 13 years old experience confusional arousals. [62] About 17% of children sleepwalk, with the disorder being more common among boys than girls, [62] the peak ages of sleepwalking are from 8 to 12 years old. [62] A different systematic review offers a high range of prevalence rates of sleep bruxism for ...

  9. γ-Hydroxybutyric acid - Wikipedia

    en.wikipedia.org/wiki/Γ-hydroxybutyric_acid

    Sodium oxybate is approved by the U.S. Food and Drug Administration for the treatment of cataplexy associated with narcolepsy [21] and excessive daytime sleepiness (EDS) associated with narcolepsy. [22] GHB has been shown to reliably increase slow-wave sleep [23] [24] [25] and decrease the tendency for REM sleep in modified multiple sleep ...

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