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A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. [1] Lower urinary tract infections may involve the bladder (cystitis) or urethra while upper urinary tract infections affect the kidney (pyelonephritis). [10]
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension, kidney scarring, and end-stage kidney disease. [44]
A UTI vaccine is a vaccine used for prevention of recurrent urinary tract infections (UTIs). [1] [2] A number of UTI vaccines have been developed and/or marketed.[1] [2] [3] These include Uromune (MV-140; sublingual spray), UroVaxom (OM-89, OM-8980; oral tablet), [4] Solco-Urovac (Strovac; vaginal suppository or intramuscular injection), [5] [6] ExPEC4V (V10, JNJ-63871860; intramuscular ...
Uromune, also known by its developmental code name MV-140, is a polyvalent bacterial vaccine which is used and is being developed for prevention of recurrent urinary tract infections (UTIs). [ 1 ] [ 2 ] [ 3 ] In clinical studies , it has been found to reduce total number of UTIs by about 70%, to increase UTI-free rates from around 25% to 57% ...
The combination was approved for medical use in the United States in February 2024. [1]In January 2024, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Exblifep, intended for the treatment of urinary tract infections and pneumonia in adults. [2]
Because it measures the thickness of the bladder wall, it is useful in cases of recurrent Urinary tract infections. [13] One study found that, in contrast to simple recurrent UTIs, which typically have a bladder wall thickness of less than 3 mm, cystitis cystica is indicated by values of bladder wall thickness greater than 3 mm. [14]
Risk factors include sexual intercourse, prior urinary tract infections, diabetes, structural problems of the urinary tract, and spermicide use. [2] [3] The mechanism of infection is usually spread up the urinary tract. [2] Less often infection occurs through the bloodstream. [1] Diagnosis is typically based on symptoms and supported by ...
Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia. [1] [2] [3] It contains meropenem, a beta-lactam antibiotic, and vaborbactam, a beta-lactamase inhibitor. [3]
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