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The lack of PFK blocks the completion of the glycolytic pathway. Therefore, all products past the block would be deficient, including Adenosine triphosphate (ATP). It may affect humans as well as other mammals (especially dogs). [4] It was named after the Japanese physician Seiichiro Tarui (b. 1927), who first observed the condition in 1965. [5]
PFK belongs to the phosphofructokinase B (PfkB) family of sugar kinases. [7] Other members of this family (also known as the Ribokinase family) include ribokinase (RK), adenosine kinase (AK), inosine kinase, and 1-phosphofructokinase. [7] [8] [9] The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs.
The PFKFB3 gene is mapped to single locus on chromosome 10 (10p15-p14). [5] [6] It spans a region of 32.5kb with an open reading frame that is 5,675bp long.It is estimated to consist of 19 exons, of which 15 are regularly expressed. [8]
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. [1] [2] [note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.
President-elect Donald Trump has once again sparked a media firestorm with his latest round of off-the-cuff remarks, this time suggesting that the U.S. should recover the Panama Canal, purchase ...
In a fractious America, there’s still one thing that people can agree on: Shaboozey’s “A Bar Song (Tipsy).” The Virginian’s country flip of an old J-Kwon hit rang out from bars ...
Just before the College Football Playoff kicks off, Dan Wetzel, Ross Dellenger, and SI's Forde provide a final preview of the 12-team bracket. They discuss the potential for five to six different ...
The pathway is antagonized by various factors including PTEN, [7] GSK3B, [2] and HB9. [5] In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation. This pathway is necessary, however, to promote growth and proliferation over differentiation of adult stem cells, neural stem cells specifically. [2]