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Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal development, and the molecular basis for neuroplasticity and ...
Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [7] [8] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5.
Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. Dysfunction in the production of Arc protein has been implicated as an important factor in understanding various neurological conditions, including amnesia , [ 9 ] Alzheimer ...
A bioinformatics network analysis is one approach to this problem. Network analyses methodologies provide a generalized, systems overview of a molecular pathway. One final complication to consider is the comorbidity of neurogenomic genes. Several disorders, especially at the more severe ends of the spectrum tend to be comorbid with each other.
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), [2] GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety of different pathways.
Can act as a stress limiting factor. [18] [19] [20] May have a direct or indirect effect on body temperature and alleviating hypothermia. [21] [22] [23] Can normalize blood pressure and myocardial contraction. [9] [24] It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have ...
83433 Ensembl ENSG00000095970 ENSMUSG00000023992 UniProt Q9NZC2 Q99NH8 RefSeq (mRNA) NM_001271821 NM_018965 NM_001272078 NM_031254 RefSeq (protein) NP_001258750 NP_061838 NP_001259007 NP_112544 Location (UCSC) Chr 6: 41.16 – 41.16 Mb Chr 17: 48.65 – 48.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in ...