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  2. Catechol - Wikipedia

    en.wikipedia.org/wiki/Catechol

    Catechol (/ ˈ k æ t ɪ tʃ ɒ l / or / ˈ k æ t ɪ k ɒ l /), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C 6 H 4 (OH) 2.It is the ortho isomer of the three isomeric benzenediols.

  3. Catecholamine - Wikipedia

    en.wikipedia.org/wiki/Catecholamine

    Catechol. A catecholamine (/ ˌ k æ t ə ˈ k oʊ l ə m iː n /; abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine. [1] Catechol can be either a free molecule or a substituent of a larger molecule, where it represents a 1,2 ...

  4. Catechol-O-methyltransferase - Wikipedia

    en.wikipedia.org/wiki/Catechol-O-methyltransferase

    Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes.[5] [6]Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. [7]

  5. Catechol-O-methyltransferase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Catechol-O-methyltransfer...

    Metabolism of levodopa by catechol-O-methyltransferase (COMT) and aromatic L-amino acid decarboxylase (AADC). COMT inhibitors prevent the conversion of levodopa to 3- O -methyldopa. A catechol- O -methyltransferase inhibitor ( COMT inhibitor ) is a drug that inhibits the enzyme catechol- O -methyltransferase .

  6. Sympathomimetic drug - Wikipedia

    en.wikipedia.org/wiki/Sympathomimetic_drug

    [medical citation needed] For maximum sympathomimetic activity, a drug must have: Amine group two carbons away from an aromatic group; A hydroxyl group at the chiral beta position in the R-configuration; Hydroxyl groups in the meta and para position of the aromatic ring to form a catechol which is essential for receptor binding

  7. Neluxicapone - Wikipedia

    en.wikipedia.org/wiki/Neluxicapone

    Neluxicapone (INN Tooltip International Nonproprietary Name) is a catechol O-methyltransferase (COMT) inhibitor which has not been marketed as of 2024. [1] [2] [3] The drug is a nitrocatechol and is structurally related to other catechol COMT inhibitors like entacapone, tolcapone, and nebicapone.

  8. Category:Catechols - Wikipedia

    en.wikipedia.org/wiki/Category:Catechols

    Catechol ethers (5 C, 71 P) Catecholamines (5 C, 51 P) Pages in category "Catechols" The following 140 pages are in this category, out of 140 total.

  9. Catechol 1,2-dioxygenase - Wikipedia

    en.wikipedia.org/wiki/Catechol_1,2-dioxygenase

    Figure 1. The overall reaction of catechol 1,2-dioxygenase. Using a non-heme iron(III) complex, 1,2-CTD is able to oxidatively cleave catechol into cis,cis-muconic acid. More specifically, 1,2-CTD is an intradiol dioxygenase, a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe 3 ...