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HIV evolved from the simian immunodeficiency virus (SIV), present in numerous species of primates in West Africa and Central Africa, in the early 20th century.SIV jumped from primates to humans several times, although the primary strain of HIV responsible for the global pandemic, HIV-1 group M, is traceable to the region surrounding Kinshasa, [11] likely having initially crossed from ...
Plasma Economy (Chinese: 血浆经济) was a 1991–1995 plasmapheresis campaign by the Henan provincial government in China, in which blood plasma was extracted in exchange for money. The campaign attracted 3 million donors, most of whom lived in rural China, and it is estimated at least 40% of the blood donors subsequently contracted HIV. [1]
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. [1] There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy ...
The study found a 39% lower HIV infection rate in women using 1% tenofovir gel compared with women using a placebo gel. In addition, tenofovir gel was shown to be safe as tested. [ 21 ] The results of the CAPRISA 004 trial provide statistically significant evidence that ARVs, topically applied to the vaginal mucosa, can offer protection against ...
Shen Hongbing is the current Director of Chinese CDC. [1]The CCDC administers a number of laboratories across China, including the biosafety level 2 facility at the Wuhan Center for Disease Control (sometimes confused with the nearby Wuhan Institute of Virology), [6] which received global media coverage during the COVID-19 pandemic for its research into SARS-like coronaviruses of bat origin.
Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. [1] It is also used to treat chronic hepatitis B when other options are not possible. [1] It is effective against both HIV-1 and HIV-2. [1] It is typically used in combination with other antiretrovirals such as zidovudine, dolutegravir, and ...
It was developed to increase interactions with HIV-1 protease and to be more resistant against HIV-1 protease mutations. With a K d ( dissociation constant ) of 4.5 x 10 −12 M, darunavir has a much stronger interaction with PR and its dissociation constant is 1/100 to 1/1000 of other protease inhibitors. [ 19 ]
For HIV infection that has not previously been treated, the United States Department of Health and Human Services Panel on Antiretroviral Guidelines recommends the use of efavirenz in combination with tenofovir/emtricitabine (Truvada) as one of the preferred NNRTI-based regimens in adults and adolescents [9] and children.
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