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On the other hand, healthy infants and children who acquire CMV after birth have few, if any, symptoms or complications. However, infants born preterm and infected with CMV after birth (especially via breastmilk [8]) may experience cognitive and motor impairments later in life. [9] [10] Symptoms associated with CMV, such as hearing loss, can ...
Cytomegalovirus (CMV) is the most common congenital viral infection, usually transmitted through the placenta during pregnancy. Most neonates with congenital CMV infection will not have any symptoms, but a minority of infected newborns will have symptomatic infection.
CMV placentitis. When physical examination of the newborn shows signs of a vertically transmitted infection, the examiner may test blood, urine, and spinal fluid for evidence of the infections listed above. Diagnosis can be confirmed by culture of one of the specific pathogens or by increased levels of IgM against the pathogen. [citation needed]
Cytomegalic inclusion body disease (CIBD) also known as cytomegalic inclusion disease (CID) is a series of signs and symptoms caused by cytomegalovirus infection, toxoplasmosis or other rare infections such as herpes or rubella viruses. It can produce massive calcification of the central nervous system, and often the kidneys. [1]
The CMV pp65 assay is widely used for monitoring CMV infection and its response to antiviral treatment in people who are under immunosuppressive therapy and have had renal transplantation surgery, as the antigenemia results are obtained about 5 days before the onset of symptomatic CMV disease.
Most commonly, valganciclovir or ganciclovir are used as first-line antiviral therapy for congenital CMV. [11] If the cause is a malignancy, the patient should receive cancer treatment such as chemotherapy. [6] Overall, treatment of the blueberry muffin baby is centered around the underlying cause.
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Diseases associated with HHV-5 include mononucleosis and pneumonia, [4] [5] and congenital CMV in infants can lead to deafness and ambulatory problems. [6] In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses. [7]