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The results showed 0.8% terconazole mycologic cure rates were 83.3% within 1–3 days of starting treatment, 83.3% within 8–11 days of treatment and 58.3% within 30–35 days of treatment. [5] The suppository is more effective after a long-term follow-up than terconazole as a cream or other intravaginal treatments.
The number of cases of vaginal yeast infection is not entirely clear because it is not a reportable disease and it is commonly diagnosed clinically without laboratory confirmation. [ 37 ] Candidiasis is one of the three most common vaginal infections along with bacterial vaginosis and trichomonas . [ 3 ]
Topical antifungal drugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus.
Oral candidiasis is the most common fungal infection of the mouth, [77] and it also represents the most common opportunistic oral infection in humans. [78] Infections of the mouth occur in about 6% of babies less than a month old. [7] About 20% of those receiving chemotherapy for cancer and 20% of those with AIDS also develop the disease. [7]
Fluconazole was patented in 1981 and came into commercial use in 1988. [7] It is on the World Health Organization's List of Essential Medicines. [8] Fluconazole is available as a generic medication. [5] In 2022, it was the 160th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [9] [10]
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea, cutaneous candidiasis, pityriasis versicolor, dandruff, and seborrheic dermatitis. [12]
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