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Therefore, lidocaine is suitable for infiltration, block, and surface anaesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias; lidocaine, though, has the advantage of a rapid onset of action. [10] Lidocaine is one of the most commonly used local anaesthetics in dentistry.
A double-blind randomized intraindividual study of lidocaine versus prilocaine in tumescent anesthesia for liposuction revealed no differences in efficacy or tolerability, except that lidocaine had a slightly more rapid onset of action. [9]
Lidocaine's half-life in the body is about 1.5–2 hours. [2] The time it takes for the anesthetic medication to prevent pain in the area (speed of onset) and length of time that the area does not have painful sensations are considerations when choosing an appropriate approach to dental treatment.
It has quick onset of action, short duration of action, and undergoes hepatic elimination. [11] Myoclonus, pain at the site of the injection, post-operative nausea and vomiting are common. [12] While common, the incidence and severity myoclonus can be reduced with pretreatment lidocaine without affecting hemodynamic stability of the patient. [12]
Although having many unwanted side-effects, a slow onset of action and recovery rate it was a big success and at the time the most potent neuromuscular drug available. Pancuronium and some other neuromuscular blocking agents block M2-receptors and therefore affect the vagus nerve , leading to hypotension and tachycardia .
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Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
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