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  2. Illumina dye sequencing - Wikipedia

    en.wikipedia.org/wiki/Illumina_dye_sequencing

    The reversible terminated chemistry concept was invented by Bruno Canard and Simon Sarfati at the Pasteur Institute in Paris. [1] [2] It was developed by Shankar Balasubramanian and David Klenerman of Cambridge University, [3] who subsequently founded Solexa, a company later acquired by Illumina. This sequencing method is based on reversible ...

  3. Massive parallel sequencing - Wikipedia

    en.wikipedia.org/wiki/Massive_parallel_sequencing

    Sequencing by reversible terminator chemistry can be a four-colour cycle such as used by Illumina/Solexa, or a one-colour cycle such as used by Helicos BioSciences. Helicos BioSciences used “virtual Terminators”, which are unblocked terminators with a second nucleoside analogue that acts as an inhibitor.

  4. DNA sequencing - Wikipedia

    en.wikipedia.org/wiki/DNA_sequencing

    Solexa, now part of Illumina, was founded by Shankar Balasubramanian and David Klenerman in 1998, and developed a sequencing method based on reversible dye-terminators technology, and engineered polymerases. [108] The reversible terminated chemistry concept was invented by Bruno Canard and Simon Sarfati at the Pasteur Institute in Paris.

  5. Dideoxynucleotide - Wikipedia

    en.wikipedia.org/wiki/Dideoxynucleotide

    Dideoxynucleotides are useful in the sequencing of DNA in combination with electrophoresis.A DNA sample that undergoes PCR (polymerase chain reaction) in a mixture containing all four deoxynucleotides and one dideoxynucleotide will produce strands of length equal to the position of each base of the type that complements the type having a dideoxynucleotide present.

  6. Reversible-deactivation radical polymerization - Wikipedia

    en.wikipedia.org/wiki/Reversible-deactivation...

    There is a mode of polymerization referred to as reversible-deactivation polymerization which is distinct from living polymerization, despite some common features. Living polymerization requires a complete absence of termination reactions, whereas reversible-deactivation polymerization may contain a similar fraction of termination as conventional polymerization with the same concentration of ...

  7. Terminator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Terminator_(genetics)

    In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.This sequence mediates transcriptional termination by providing signals in the newly synthesized transcript RNA that trigger processes which release the transcript RNA from the transcriptional complex.

  8. Termination signal - Wikipedia

    en.wikipedia.org/wiki/Termination_signal

    Traditionally, the termination signal for translation is a 3 nucleobase sequence called a stop codon. [2] Research has shown that the nucleobases surrounding the stop codon can impact termination efficiency. [2] Specifically, the 4th base (nucleobase directly following the stop codon) has a significant impact on the termination efficiency. [2]

  9. Reversible reaction - Wikipedia

    en.wikipedia.org/wiki/Reversible_reaction

    A and B can react to form C and D or, in the reverse reaction, C and D can react to form A and B. This is distinct from a reversible process in thermodynamics. Weak acids and bases undergo reversible reactions. For example, carbonic acid: H 2 CO 3 (l) + H 2 O (l) ⇌ HCO 3 − (aq) + H 3 O + (aq).