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The four-α-helix bundle family (InterPro: IPR009079): member cytokines have three-dimensional structures with a bundle of four α-helices. This family, in turn, is divided into three sub-families: the IL-2 subfamily. This is the largest family. It contains several non-immunological cytokines including erythropoietin (EPO) and thrombopoietin ...
CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure.
IL-30 is a protein from the IL-6 cytokine family with molecular weight of 28 kilodaltons (thus the name IL27-p28). It is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6. [5] The human gene for IL-30 is located on chromosome 16p11. [5]
Interleukin 3 (IL3) is a cytokine that regulates hematopoiesis by controlling the production, differentiation and function of granulocytes and macrophages. [ 15 ] [ 16 ] The protein, which exists in vivo as a monomer, is produced in activated T cells and mast cells, [ 15 ] [ 16 ] and is activated by the cleavage of an N-terminal signal sequence.
IL-2 is a member of a specific family of cytokines, each member of which has a four alpha helix bundle; this cytokine family also includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a IL-2 receptor, a complex consisting of three chains, termed alpha , beta and gamma . The gamma chain is common to all family members. [6]
The IL-10 family is one of the important types of cytokines, that can stop the inflammation. In general. these cytokines have a helical structure of homodimers. [4] The difference that the members of IL-10 family have between each other is that they have various receptor-binding residues, which help with interaction with specific cytokine receptors. [5]
5008 18413 Ensembl ENSG00000099985 ENSMUSG00000058755 UniProt P13725 P53347 RefSeq (mRNA) NM_020530 NM_001319108 NM_001013365 RefSeq (protein) NP_001306037 NP_065391 NP_001013383 Location (UCSC) Chr 22: 30.26 – 30.27 Mb Chr 11: 4.19 – 4.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM ...
Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 . In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors.
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