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Azadirachta indica, commonly known as neem, margosa, nimtree or Indian lilac, [3] is a tree in the mahogany family Meliaceae. It is one of the two species in the genus Azadirachta . It is native to the Indian subcontinent and to parts of Southeast Asia , but is naturalized and grown around the world in tropical and subtropical areas.
Azadirachtin is formed via an elaborate biosynthetic pathway, but is believed that the steroid tirucallol is the precursor to the neem triterpenoid secondary metabolites. Tirucallol is formed from two units of farnesyl diphosphate (FPP) to form a C 30 triterpene, but then loses three methyl groups to become a C 27 steroid.
Nimbin can be quantified in neem using advanced mass spectrometry [15] or HPLC techniques. [16] The concentration of this chemical in the plant (among other chemicals) can be impacted by various factors such as the different parts of the tree in which they can be found or tree age. [15] Nimbin can be found in neem leaves, seeds and bark.
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Formulations that include neem oil have found wide usage as a biopesticide for horticulturists [4] and for organic farming, as it repels a wide variety of insect pests including mealy bugs, beet armyworms, aphids, cabbage worms, thrips, whiteflies, mites, fungus gnats, beetles, moth larvae, mushroom flies, leaf miners, caterpillars, locusts, nematodes and Japanese beetles.
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