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The name "pyogenic granuloma" is misleading, as it is neither pyogenic or a true granuloma. Rather, it is a capillary hemangioma of lobular subtype, which is why such a lesion is prone to bleeding. [5] It is also not truly pyogenic (pus-producing), as the cause is hormonal or traumatic and has no association with infection or pus production.
Instead, the three are associated with each other because they appear frequently on gingiva: pyogenic granuloma and peripheral giant cell granuloma. Some researchers believe peripheral ossifying fibromas to be related to pyogenic fibromas and, in some instances, are the result of a pyogenic granuloma which has undergone fibrosis and calcification.
682.7 Cellulitis/abscess, foot; 682.9 Cellulitis/abscess, unspec. 683 Lymphadenitis, acute; 684 Impetigo; 685 Pilonidal cyst. 685.0 Pilonidal cyst w/ abscess; 685.1 Pilonidal cyst, unspec. 686 Other local infections of skin and subcutaneous tissue. 686.0 Pyoderma; 686.1 Pyogenic granuloma of skin and subcutaneous tissue
Pyogenic granuloma (eruptive hemangioma, granulation tissue-type hemangioma, granuloma gravidarum, lobular capillary hemangioma, pregnancy tumor, tumor of pregnancy) Pyogenic granuloma; Pyostomatitis vegetans; Recurrent aphthous stomatitis (aphthosis, canker sores, recurrent oral aphthae) Recurrent intraoral herpes simplex infection
A rare [10] syndromic association called pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA syndrome), a type of autoinflammatory disorder, is associated with mutations in the proline-serine-threonine phosphatase-interacting 1 gene . [10] [11]
PAPA syndrome is inherited in an autosomal dominant fashion, which means that if one parent is affected, there is a 100% chance that a child will inherit the disease from a homozygous affected parent and a 50% chance that a child will inherit the disease from an affected heterozygous parent.
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Peripheral giant-cell granuloma (PGCG) is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. These three diseases are ...