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The following bones develop in humans via Intramembranous ossification: [3] Flat bones of the face; Most of the bones of the skull; Clavicles; Other bone that formed by intramembranous ossification are: cortices of tubular and flat bones as well as the calvaria, upper facial bones, tympanic temporal bone, vomer, and medial pterygoid process. [4]
Intramembranous ossification forms the flat bones of the skull, mandible and hip bone.. Osteoblasts cluster together to create an ossification center. They then start secreting osteoid, an unmineralized collagen-proteoglycan matrix that has the ability to bind calcium.
The formation of bone is called ossification. During the fetal stage of development this occurs by two processes: intramembranous ossification and endochondral ossification. [42] Intramembranous ossification involves the formation of bone from connective tissue whereas endochondral ossification involves the formation of bone from cartilage.
An ossification center is a point where ossification of the hyaline cartilage begins. The first step in ossification is that the chondrocytes at this point become hypertrophic and arrange themselves in rows. [1] The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other.
It usually consists of only endochondral ossification. Sometimes, intramembranous ossification occurs together with endochondral ossification. Intramembranous ossification, mediated by the periosteal layer of bone, occurs with the formation of callus. For endochondral ossification, deposition of bone only occurs after the mineralised cartilage.
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The “spacing effect” refers to a phenomenon whereby learning, or the creation of a memory, occurs more effectively when information, or exposure to a stimulus, is spaced out.
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