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101180976 n/a Ensembl ENSG00000272395 n/a UniProt K9M1U5 n/a RefSeq (mRNA) NM_001276254 n/a RefSeq (protein) NP_001263183 n/a Location (UCSC) Chr 19: 39.25 – 39.25 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family. This gene encodes the ...
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...
Interferon alfa or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography.
Delayed IFN-I response contributes to the pathogenic inflammation (cytokine storm) seen in later stages of COVID-19 disease. [41] Application of IFN-I prior to (or in the very early stages of) viral infection can be protective, [37] which should be validated in randomized clinical trials. [41]
SOCS1 inhibits type I IFN signaling by inhibiting JAKs and binding phosphorylated Tyk2. [9] USP18 binds to the C terminus of IFNAR2. [9] USP18 may regulate type I IFN signaling by interfering with ternary complex formation, not through its peptidase function. [7] Loss of USP18 results in an inflammatory interferon-mediated CNS disease. [3]
From January 2008 to April 2009, if you bought shares in companies when Meredith R. Spangler joined the board, and sold them when she left, you would have a -83.0 percent return on your investment, compared to a -44.7 percent return from the S&P 500.
Stock returns do not include dividends. All directors refers to people who sat on the board of at least one Fortune 100 company between 2008 and 2012. The Pay Pals project relies on financial research conducted by the Center for Economic Policy and Research. Sources: Google Finance, Yahoo Finance .
The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.