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The accurate diagnosis of circumvallate placenta during pregnancy can have significant implications in the recognition of patients who are at risk of complications. Although the ability of sonography to accurately diagnosis circumvallate placenta during pregnancy is quite limited, research studies continue to emerge at the possibility of doing so.
In the early stages of placental abruption, there may be no symptoms. [1] When symptoms develop, they tend to develop suddenly. Common symptoms include: sudden-onset abdominal pain [5] [8] contractions that seem continuous and do not stop [5] vaginal bleeding [5] [8] enlarged uterus (disproportionate to the gestational age of the fetus) [5]
Especially when these symptoms are evident at early stages of pregnancy. [3] The abnormal invasion of the trophoblast cells, lack of important growth factors such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), has an association with the onset of placental disease.
Histopathology of placenta with increased syncytial knotting of chorionic villi, with two knots pointed out. The following characteristics of placentas have been said to be associated with placental insufficiency, however all of them occur in normal healthy placentas and full term healthy births, so none of them can be used to accurately diagnose placental insufficiency: [citation needed]
Circumvallate placenta A circumvallate placenta refers to when the foetal membrane wraps twice around, over the foetal side around the edge of the placenta . This is to compensate for an undersized chorionic plate resulting in a decreased nutritional supply to the foetus.
Treatment depends on diagnosis and may include hormonal therapy, iv fluids, blood transfusion, and/or a dilation and curettage. Internal bleeding requires laparoscopy or abdominal surgery, in rare and extreme cases a hysterectomy is performed.
An impaired placenta cannot support the pregnancy and this may lead to the loss of a chromosomally normal baby. [5] On the other hand, an apparently normal diploid fetus may experience problems with growth or development due to the effects of uniparental disomy (UPD).
Normally the maternal circulation and the fetal circulation are kept from direct contact with each other, with gas and nutrient exchange taking place across a membrane in the placenta made of two layers, the syncytiotrophoblast and the cytotrophoblast. Fetal-maternal haemorrhage occurs when this membrane ceases to function as a barrier and ...