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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
Whooping cough (/ ˈ h uː p ɪ ŋ / or / ˈ w uː p ɪ ŋ /), also known as pertussis or the 100-day cough, is a highly contagious, vaccine-preventable bacterial disease. [1] [10] Initial symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough, but these are followed by two or three months of severe coughing fits. [1]
Due to the fact B. pertussis is only found in humans and shows little genetic variation from the other Bordetella species, it is thought that it was derived from a common ancestor in recent years. B. parapertussis can affect both humans and other mammals, primarily sheep. Similar to B. pertussis, it causes whooping cough in babies. Yet, when ...
Prescribing antibiotics for laryngitis is not a suggested practice. [16] The antibiotics penicillin V and erythromycin are not effective for treating acute laryngitis. [ 16 ] Erythromycin may improve voice disturbances after a week and cough after 2 weeks, but any modest subjective benefit is not greater than the adverse effects, cost, and the ...
Whooping cough cases are skyrocketing in New York City, according to shocking new data that emerges as many unvaccinated migrants continue to pour into the Big Apple. NYC whooping cough cases ...
Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. [1] CyaA plays a particular role in the early phases of airway colonization.
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
Pertussis toxin (PT) is a protein-based AB 5-type exotoxin produced by the bacterium Bordetella pertussis, [2] which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. [ 3 ]