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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. [7]
The VIGOR trial results were published in 2000 in the New England Journal of Medicine [47] Bombardier and her research team claimed that there was "an increase in myocardial infarction in the patients given rofecoxib (0.4%) compared with those given naproxen (0.1%)" and "patients given naproxen experienced 121 side effects compared with 56 in ...
The most common side effects include edema, abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, accidental injury, dizziness, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, and rash. [1] It was approved for medical use in the United States in May 2018. [3]
Within a year, Sun Life began sending out direct mail. [24] They introduced their very first plan for people aged over 50 in 1979. [25] In 1982, they became the world's first life assurance company to announce a £200,000 non-medical limit. [26] In 1992, French insurer UAP became Sun Life Assurance Society's major shareholder. [27]
For people over the age of 65 years old, the balance between the benefits of pain-relief medications such as NSAIDS and the potential for adverse effects has not been well determined. [50] There is some evidence suggesting that, for some people, use of NSAIDs (or other anti-inflammatories) may contribute to the initiation of chronic pain. [51]
Mayo Clinic Arizona is a multi-campus medical clinic and tertiary medical center in Phoenix, Arizona. Its two main campuses are the outpatient clinic building, situated in east Scottsdale, Arizona, and the Arizona Hospital, located in north Phoenix, Arizona. [ 1 ]
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The terminal half-life in plasma ranged from 5.4 to 8.6 hours (mean =6.5 hours). The half-life in synovial fluid is considerably longer than in plasma, and the concentration in synovial fluid 24 hours after administration would be expected to result in a substantial COX-2 inhibition. This fact can explain why some users may suffice with once ...
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