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The enzyme fructose bisphosphatase (EC 3.1.3.11; systematic name D-fructose-1,6-bisphosphate 1-phosphohydrolase) catalyses the conversion of fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis and the Calvin cycle, which are both anabolic pathways: [1] [2] D-fructose 1,6-bisphosphate + H 2 O = D-fructose 6-phosphate + phosphate ...
Fructose 1,6-bisphosphate, known in older publications as Harden-Young ester, is fructose sugar phosphorylated on carbons 1 and 6 (i.e., is a fructosephosphate). The β-D-form of this compound is common in cells. [1] Upon entering the cell, most glucose and fructose is converted to fructose 1,6-bisphosphate. [2] [3]
14121 Ensembl ENSG00000165140 ENSMUSG00000069805 UniProt P09467 Q9QXD6 RefSeq (mRNA) NM_000507 NM_001127628 NM_019395 RefSeq (protein) NP_000498 NP_001121100 NP_062268 Location (UCSC) Chr 9: 94.6 – 94.64 Mb Chr 13: 63.01 – 63.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene. Function Fructose ...
A molecule of GTP is hydrolyzed to GDP during this reaction. The next steps in the reaction are the same as reversed glycolysis. However, fructose 1,6-bisphosphatase converts fructose 1,6-bisphosphate to fructose 6-phosphate, using one water molecule and releasing one phosphate (in glycolysis, phosphofructokinase 1 converts F6P and ATP to F1 ...
ATP + fructose-6-phosphate → Fructose-1,6-bisphosphate + ADP But during gluconeogenesis (i.e. synthesis of glucose from pyruvate and other compounds) the reverse reaction takes place, being catalyzed by fructose-1,6-bisphosphatase (FBPase-1).
Phosphofructokinase-1 (PFK-1) is one of the most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors. PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ...
When too much fructose-1,6-bisphosphate is produced, it inhibited the production of more PFK-1 activator. The enzyme is also inhibited by PEP, which is a reagent of pyruvate kinase. The product of glucose-1,6-bisphosphate synthase (glucose-1,6-bisphosphate) activates pyruvate kinase. Glucose-1,6-bisphosphate synthase appears to be activated by ...
An example of a coupled reaction is the phosphorylation of fructose-6-phosphate to form the intermediate fructose-1,6-bisphosphate by the enzyme phosphofructokinase accompanied by the hydrolysis of ATP in the pathway of glycolysis. The resulting chemical reaction within the metabolic pathway is highly thermodynamically favorable and, as a ...