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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
Koch's postulates (/ k ɒ x / KOKH) [2] are four criteria designed to establish a causal relationship between a microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle , and the statements were refined and published by Koch in 1890. [ 3 ]
2. The cell is the most basic unit of life. Schleiden's theory of free cell formation through crystallization was refuted in the 1850s by Robert Remak, Rudolf Virchow, and Albert Kolliker. [5] In 1855, Rudolf Virchow added the third tenet to cell theory. In Latin, this tenet states Omnis cellula e cellula. This translated to: 3.
In 1861, an unknown Vienna high-school teacher named Joseph Loschmidt published, at his own expense, a booklet entitled Chemische Studien I, containing pioneering molecular images which showed both "ringed" structures as well as double-bonded structures, such as: [13] Joseph Loschmidt's molecule drawings of ethylene H 2 C=CH 2 and acetylene HC ...
Folded, 3-D structure of ribonuclease A. Anfinsen's dogma, also known as the thermodynamic hypothesis, is a postulate in molecular biology.It states that, at least for a small globular protein in its standard physiological environment, the native structure is determined only by the protein's amino acid sequence. [1]
The research in his molecular spectroscopy laboratory focused on the discovery and elucidation of excitation mechanisms, with particular application to photochemical and biophysical problems. His most important achievements include identifying triplet states as source of phosphorescence emission, formulating the Kasha rule on fluorescence , and ...
Biologists, however, have not limited their application of the term neo-Darwinism to the historical synthesis. For example, Ernst Mayr wrote in 1984 that: The term neo-Darwinism for the synthetic theory [of the early 20th century] is sometimes considered wrong, because the term neo-Darwinism was coined by Romanes in 1895 as a designation of Weismann's theory.