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PPI use and dementia may both be influenced by similar risk factors, Dr. Lewis H. Kuller of the University of Pittsburgh wrote in an editorial accompanying the results.
There is a purported correlation (but no proven causal link) between the use of PPIs and the risk of dementia. [6] However, this remain controversial as chronic and co-morbid pathology, and resultant polypharmacy (including increased consumption of PPIs), will probably itself also give rise to an increased risk of dementia as a whole.
[58] [59] [22] There are associations with an increased risk of stroke, but this appears to be more likely to occur in people who already have an elevated risk. [ 60 ] One suggested mechanism for cardiovascular effects is because PPIs bind and inhibit dimethylargininase , the enzyme that degrades asymmetric dimethylarginine (ADMA), resulting in ...
Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.
The study, which followed healthy older adults for 5 years, found that antibiotic use was not associated with an increased risk of cognitive impairment and dementia.
Many risk factors for dementia overlap, so engaging in adequate physical activity, eating a Mediterranean type of diet, maintaining social engagement, and following up with your primary-care ...
Pantoprazole was first prepared in April 1985 by a small group of scale-up chemists. It is a dimethoxy-substituted pyridine bound to a fluoroalkoxy substituted benzimidazole. [ 5 ] Pantoprazole sodium is available as gastroresistant or delayed release tablets and as lyophilized powder for intravenous use.
Some drugs used to treat type 2 diabetes could also help lower a person’s risk of neurodegenerative diseases, such as Alzheimer’s. Image credit: martin-dm/Getty Images.
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