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A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. [1] [2] It is a form of sickle cell crisis.Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries.
The crisis is a common complication in sickle-cell patients and can be associated with one or more symptoms including fever, cough, excruciating pain, sputum production, shortness of breath, or low oxygen levels. [2]
A sickle cell health crisis can escalate into life-threatening complications, but patients still struggle to get seen quickly in emergency rooms and also to get pain medicine.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]
Splenic sequestration crisis is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia.Up to 30% of these children may develop splenic sequestration crisis with a mortality rate of up to 15%.
In cases of a sickle cell bone marrow transplant, the best results come from a sibling. A sibling HLA match gives the procedure a 95% success rate, as opposed to a rate of around 78% with an ...
Listed below are some of the conditions that may put a patient at risk of developing aplastic crisis if there is a disruption in erythropoiesis. [2] Hemolytic disorders - hereditary spherocytosis; Hemoglobinopathies. - sickle cell disease, thalassemias; Red cell enzymopathies - G6PD Deficiency, PK Deficiency; Autoimmune hemolytic anemias
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