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Thiamazole, also known as methimazole, is a medication used to treat hyperthyroidism. [2] This includes Graves disease, toxic multinodular goiter, and thyrotoxic crisis. [2] It is taken by mouth. [2] Full effects may take a few weeks to occur. [3] Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal ...
A randomized control trial testing single dose treatment for Graves' found methimazole achieved euthyroidism (normal thyroid function that occurs within normal serum levels of TSH and T4 [23]) more effectively after 12 weeks than did propylthiouracil (77.1% on methimazole 15 mg vs 19.4% in the propylthiouracil 150 mg groups). [24]
A metered-dose transdermal spray (MDTS) delivers a drug to the surface of the skin and is absorbed into the circulation on a sustained basis. It works in a similar manner to a transdermal patch or topical gel. The drug is delivered by a device placed gently against the skin and triggered, causing it to release a light spray containing a ...
Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution. Examples include transdermal patches used for medicine delivery. The drug is administered in the form of a patch or ointment that delivers the drug into the circulation for systemic effect.
A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of medication delivery (such as oral, topical, intravenous, or intramuscular) is that the patch provides a controlled ...
Topical drug delivery (TDD) is a route of drug administration that allows the topical formulation to be delivered across the skin upon application, hence producing a localized effect to treat skin disorders like eczema.
The most abundant transdermal drug administration route currently is via hypodermic needles, transdermal patches, and topical creams. [21] However, these routes have limited therapeutic effects because stratum corneum serves as a barrier that reduces the entry of drug molecules into the systemic circulation and target tissues. [ 21 ]
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T 3 and T 4 . It is on the World Health Organization's List of Essential Medicines.