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Naloxegol. Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid -induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]
Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome -associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Glycerin suppositories used as laxatives. Laxatives, purgatives, or aperientsare substances that loosen stools[1]and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have.
Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. [1] [5] The medication is taken by mouth or via the rectum. [1] [6] It typically begins working in around 30 minutes when given by rectum and within twelve hours when given by mouth. [3]
Colon cleansing supplements may lead to dehydration, Hussan says. If you have a pre-existing kidney condition, cleansing your colon may cause an electrolyte imbalance in the bloodstream, he adds ...
Naldemedine. Naldemedine, sold under the brand name Symproic in the US and Rizmoic in the European Union, is a medication that is used for the treatment of opioid -induced constipation in adults who have previously been treated with a laxative in the European Union, or to treat opioid induced constipation in adults with chronic non-cancer pain ...
Docusate is the common chemical and pharmaceutical name of the anion bis (2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [ 2 ][ 3 ][ 4 ] Salts of this anion, especially docusate sodium, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally. [ 1 ]
In terms of bonding, isocyanates are closely related to carbon dioxide (CO 2) and carbodiimides (C (NR) 2). The C−N=C=O unit that defines isocyanates is planar, and the N=C=O linkage is nearly linear. In phenyl isocyanate, the C=N and C=O distances are respectively 1.195 and 1.173 Å. The C−N=C angle is 134.9° and the N=C=O angle is 173.1°.