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The normal daily temperature variation is typically 0.5 °C (0.90 °F), but can be greater among people recovering from a fever. [15] An organism at optimum temperature is considered afebrile, meaning "without fever". [26] If temperature is raised, but the setpoint is not raised, then the result is hyperthermia.
On the other hand, a "normal" temperature may be a fever, if it is unusually high for that person; for example, medically frail elderly people have a decreased ability to generate body heat, so a "normal" temperature of 37.3 °C (99.1 °F) may represent a clinically significant fever. [37] [39]
Normal body temperature is around 37°C (98.6°F), and hypothermia sets in when the core body temperature gets lower than 35 °C (95 °F). [2] Usually caused by prolonged exposure to cold temperatures, hypothermia is usually treated by methods that attempt to raise the body temperature back to a normal range. [3]
In humans, hyperthermia is defined as a temperature greater than 37.5–38.3 °C (99.5–100.9 °F), depending on the reference used, that occurs without a change in the body's temperature set point. [3] [10] The normal human body temperature can be as high as 37.7 °C (99.9 °F) in the late afternoon. [2]
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
* Normal human body temperature is 36.8 °C ±0.7 °C, or 98.2 °F ±1.3 °F. The commonly given value 98.6 °F is simply the exact conversion of the nineteenth-century German standard of 37 °C. Since it does not list an acceptable range, it could therefore be said to have excess (invalid) precision.
The main diagnostic sign is an oral body temperature that averages well below 37.0 °C (98.6 °F). This overlaps with normal body temperature, which is usually within the range of 36.5–37.5 °C (97.7–99.5 °F). [5] [6] Wilson says that his diagnosis is confirmed if the patient responds to treatment with slow-release T3 (SR-T3).
In Europe, epinephrine is not recommended until the person's core temperature reaches 30 °C (86 °F), while the American Heart Association recommends up to three doses of epinephrine before a core temperature of 30 °C (86 °F) is reached. [2] Once a temperature of 30 °C (86 °F) has been reached, normal ACLS protocols should be followed. [50]