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Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar. [18]
In pooled data, from three comparative studies conducted in 200 patients with mild to moderate hypertension, 2.5 mg of levamlodipine was found to be equivalent in its blood pressure lowering efficacy to 5 mg of amlodipine. The average reduction in systolic BP was 19±3 vs 19±4, 20±2 vs 19±3 and 20±2 vs 19±3 mm of Hg recorded in standing ...
Concerning more usual adverse effects, in pooled results from 7537 patients exposed to levofloxacin in 29 clinical trials, 4.3% discontinued treatment due to adverse drug reactions. The most common adverse reactions leading to discontinuation were gastrointestinal, including nausea, vomiting, and constipation.
Amlodipine was patented in 1982, and approved for medical use in 1990. [12] It is on the World Health Organization's List of Essential Medicines. [13] It is available as a generic medication. [10] [14] In 2022, it was the fifth most commonly prescribed medication in the United States, with more than 70 million prescriptions.
The drug acts more slowly than older dihydropyridines. [citation needed] It probably has fewer adverse effects, but a comparatively high potential for drug interactions. It was patented in 1984 and first approved for medical use in 1997. [2] The FDA refused to approve the drug, and lercanidipine is not marketed in the United States. [3]
Levamisole, sold under the brand name Ergamisol among others, is a medication used to treat parasitic worm infections, specifically ascariasis and hookworm infections. [1] It is taken by mouth. [2] Side effects may include abdominal pain, vomiting, headache, and dizziness. [2] Use is not recommended during breastfeeding or the third trimester ...
Tiagabine may induce seizures in those without epilepsy, particularly if they are taking another drug which lowers the seizure threshold. [5] There may be an increased risk of psychosis with tiagabine treatment, although data is mixed and inconclusive. [2] [10] Tiagabine can also reportedly interfere with visual color perception. [2]
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [2] It was patented in 1991 and came into medical use in 2002. [4] It is available as a generic medication. [5] In 2022, it was the 97th most commonly prescribed medication in the United States, with more than 6 million prescriptions. [6] [7]