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  2. G protein-coupled receptor - Wikipedia

    en.wikipedia.org/wiki/G_protein-coupled_receptor

    The seven-transmembrane α-helix structure of bovine rhodopsin. G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and ...

  3. cAMP-dependent pathway - Wikipedia

    en.wikipedia.org/wiki/CAMP-dependent_pathway

    Activated GPCRs cause a conformational change in the attached G protein complex, which results in the G s alpha subunit's exchanging GDP for GTP and separation from the beta and gamma subunits. The G s alpha subunit, in turn, activates adenylyl cyclase, which quickly converts ATP into cAMP.

  4. G protein-coupled inwardly rectifying potassium channel

    en.wikipedia.org/wiki/G_protein-coupled_inwardly...

    [1] [2] GPCRs in turn release activated G-protein βγ- subunits (G βγ) from inactive heterotrimeric G protein complexes (G αβγ). Finally, the G βγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. [ 3 ]

  5. Glucagon-like peptide-1 receptor - Wikipedia

    en.wikipedia.org/wiki/Glucagon-like_peptide-1...

    The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6.

  6. G protein - Wikipedia

    en.wikipedia.org/wiki/G_protein

    Phosducin-transducin beta-gamma complex. Beta and gamma subunits of G-protein are shown by blue and red, respectively. Guanosine diphosphate Guanosine triphosphate. G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

  7. Gq alpha subunit - Wikipedia

    en.wikipedia.org/wiki/Gq_alpha_subunit

    GPCRs function as part of a three-component system of receptor-transducer-effector. [ 1 ] [ 2 ] The transducer in this system is a heterotrimeric G protein , composed of three subunits: a Gα protein such as G αq , and a complex of two tightly linked proteins called Gβ and Gγ in a Gβγ complex .

  8. Rhodopsin - Wikipedia

    en.wikipedia.org/wiki/Rhodopsin

    Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene [5] and a G-protein-coupled receptor (GPCR). It is a light-sensitive receptor protein that triggers visual phototransduction in rods. Rhodopsin mediates dim light vision and thus is extremely sensitive to light. [6]

  9. Adhesion G protein-coupled receptor - Wikipedia

    en.wikipedia.org/wiki/Adhesion_G_protein-coupled...

    The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes. [8] As the vertebrate superfamily can be phylogenetically grouped into five main families, the GRAFS classification system has been proposed, which includes the glutamate, rhodopsin, adhesion, Frizzled/Taste2, and secretin GPCR families.