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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the reference chemical to which the toxicity of other dioxins and DLCs are compared. TCDD is the most toxic DLC known. Other dioxins and DLCs are assigned a scaling factor, or TEF, in comparison to TCDD. TCDD has a TEF of 1.0. Sometimes PCB 126 is also used as a reference chemical, with a TEF of 0.1.
[2] [3] For general population the most important source is food of animal origin like with other dioxin-like compounds. [ 4 ] [ 5 ] [ 6 ] The most relevant congener is 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PCDF) which is more toxic and based on relative toxicity more prevalent than other PCDFs.
The uncertainty and variability in the dose–response relationship of dioxins in terms of their toxicity, as well as the ability of dioxins to bioaccumulate, have led WHO experts to recommending very low tolerable daily intake (TDI) of dioxin, 1-4 pg/kg body weight per day, i.e. 7x10 −11 to 2.8x10 −10 g per 70-kg person per day, to allow ...
Dioxins build up primarily in fatty tissues over time (bioaccumulation), so even small exposures may eventually reach dangerous levels. In 1994, the US EPA reported that dioxins are a probable carcinogen, but noted that non-cancer effects (reproduction and sexual development, immune system) may pose a greater threat to human health.
The Dioxin Reassessment Report refers to the United States Environmental Protection Agency's scientific reassessment of the health effects of exposure to dioxins. It began in April 1991, and in 1994 was published for public review.
Regular physical activity can help with weight loss and weight maintenance. For the best results, aim to exercise at a moderate level for at least 30 minutes per day, three times per week, and ...
According to the U.S. Environmental Protection Agency (EPA), PCBs cause cancer in animals and are probable human carcinogens. [4] Moreover, because of their use as a coolant in electric transformers, PCBs still persist in built environments. [5] [6] Some PCBs share a structural similarity and toxic mode of action with dioxins. [7]
Dibenzofuran is a relatively non-toxic compound as evidenced by rats being unaffected after a 200-day diet consisting of 0.025 – 0.4% of DBF. [1] The polychlorinated dibenzofurans are however among the potentially toxic dioxins and dioxin-like compounds.
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