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Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin -regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
GLUT4: Expressed in adipose tissues and striated muscle (skeletal muscle and cardiac muscle). Is the insulin-regulated glucose transporter. Responsible for insulin-regulated glucose storage. GLUT14: Expressed in testes: similarity to GLUT3 [12]
TUG releases the GLUT4 containing vesicles (GSVs) in response to insulin stimulation which allows it to move to the plasma membrane. [2] TUG has an N-terminal ubiquitin-like protein domain (UBL1) which in similar proteins appears to participate in protein-protein interactions. [2]
n/a Ensembl ENSG00000125520 n/a UniProt Q9NR83 n/a RefSeq (mRNA) NM_020062 n/a RefSeq (protein) NP_064446 n/a Location (UCSC) Chr 20: 63.74 – 63.74 Mb n/a PubMed search n/a Wikidata View/Edit Human SLC2A4 regulator is a protein that in humans is encoded by the SLC2A4RG gene. The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier ...
GLUT4 transporters are insulin sensitive, and are found in muscle and adipose tissue. As muscle is a principal storage site for glucose and adipose tissue for triglyceride (into which glucose can be converted for storage), GLUT4 is important in post-prandial uptake of excess glucose from the bloodstream. Moreover, several recent papers show ...
David Ernest James FAA (born in Sydney in 1958) is a cell biologist who discovered the glucose transporter GLUT4.He has also been responsible for the molecular dissection of the intracellular trafficking pathways that regulate GLUT4 translocation to the cell surface, the topological mapping of the insulin signal transduction pathway, the creation of a method for studying in vivo metabolism in ...
The four-part series, titled “The Fall of Diddy,” will premiere across two nights starting Jan. 27 at 9 p.m. ET on ID. More from Variety. Diddy's Bodyguard, Intern and Producer Speak Out in ...
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.