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Dermatology Acantholysis is the loss of intercellular connections , such as desmosomes , resulting in loss of cohesion between keratinocytes , [ 1 ] seen in diseases such as pemphigus vulgaris . [ 2 ]
In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells. It is sometimes also called the chickenpox skin test and the herpes skin test. It is a simple, low-cost, and rapid office based test. [1] Tzanck cells (acantholytic cells) are found in: Herpes simplex [2] Varicella and herpes zoster
Many skin conditions require a skin biopsy for confirmation of the diagnosis. With several of these conditions there are features within the cells contained in the skin biopsy specimen that have elements in their cytoplasm or nucleus that have a characteristic appearance unique to the condition. These elements are termed inclusion bodies.
Dermatology Grover's disease ( GD ) is a polymorphic, pruritic , papulovesicular dermatosis characterized histologically by acantholysis [ 2 ] : 529 with or without dyskeratosis. [ 3 ] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient".
Skin cancer is the uncontrolled proliferation of abnormal skin cells, usually developing on skin exposed to ultraviolet radiation. Squamous cell carcinoma , basal cell carcinoma , and melanoma are the three main types of skin cancer, [ 5 ] with the former two being non-melanoma skin cancer.
Suture granuloma, with multinucleated giant cells surrounding (grey) suture material. Foreign bodies indicate a foreign body granuloma. Specific forms of multinucleated giant cells include the Touton giant cell, which contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.
Relapsing linear acantholytic dermatosis is a cutaneous condition characterized by relapsing linear erosions and crusting, histologically identical to Hailey–Hailey disease. [ 1 ] : 849 [ 2 ] It is not to be confused with transient acantholytic dermatosis .
Squamous-cell carcinoma of the skin, squamous-cell skin cancer, epidermoid carcinoma, squamous-cell epithelioma of the skin: Cutaneous squamous-cell carcinoma tends to arise from actinic keratoses (premalignant lesions); surface is usually scaly and often ulcerates (as shown here). Specialty: Dermatology, plastic surgery, otorhinolaryngology ...