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H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit . It is a potent stimulant of cAMP production, which leads to activation of protein kinase A . [ 5 ]
Histamine receptors are proteins that bind with histamine, a neurotransmitter involved in various physiological processes. There are four main types: H1, H2, H3, and H4. H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function.
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H 1 agonists promote wakefulness. [1] H 2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H 3: Betahistine is a weak Histamine 1 agonist and a very strong antagonist of the Histamine ...
Histamine H 2 receptor • CNS: Dorsal striatum (caudate nucleus and putamen), cerebral cortex (external layers), hippocampal formation, dentate nucleus of the cerebellum • Periphery: Located on parietal cells, vascular smooth muscle cells, neutrophils, mast cells, as well as on cells in the heart and uterus
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
Agonist muscles are also called prime movers since they produce most of the force, and control of an action. [6] Agonists cause a movement to occur through their own activation. [7] For example, the triceps brachii contracts, producing a shortening (concentric) contraction, during the up phase of a push-up (elbow extension).
There are also different subtypes of receptor which elicit different effects in response to the same agonist. For example, there are two types of histamine receptor: H1 and H2. Activation of the H1 subtype receptor causes contraction of smooth muscle, whereas activation of the H2 receptor stimulates gastric secretion.
Muscle energy techniques that use reflexive antagonism, such as rapid deafferentation techniques, are medical guideline techniques and protocols that make use of reflexive pathways and reciprocal inhibition as a means of switching off inflammation, pain, and protective spasm for entire synergistic muscle groups or singular muscles and soft ...