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Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.
Meaning Origin language and etymology Example(s) a-, an-not, without (alpha privative) Greek ἀ-/ἀν-(a-/an-), not, without analgesic, apathy, anencephaly: ab-from; away from Latin abduction, abdomen: abdomin-of or relating to the abdomen: Latin abdōmen, abdomen, fat around the belly abdomen, abdominal -ac: pertaining to; one afflicted with
In males, testosterone deficiency is the cause (for example, andropause or after surgical removal of the testes). Endocrine disorders that can induce bone loss include Cushing's syndrome, [4] hyperparathyroidism, [4] hyperthyroidism, [4] hypothyroidism, diabetes mellitus type 1 and 2, [64] acromegaly, and adrenal insufficiency. [62]
Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. [5] Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. [6] Osteocyte activity plays a key role in this process. Conditions ...
The functional part of bone, the bone matrix, is entirely extracellular. The bone matrix consists of protein and mineral. The protein forms the organic matrix. It is synthesized and then the mineral is added. The vast majority of the organic matrix is collagen, which provides tensile strength. The matrix is mineralized by deposition of ...
It contains the growth plate, the part of the bone that grows during childhood, and as it grows it ossifies near the diaphysis and the epiphyses. The metaphysis contains a diverse population of cells including mesenchymal stem cells , which give rise to bone and fat cells, as well as hematopoietic stem cells which give rise to a variety of ...
A long bone is one that is cylindrical in shape, being longer than it is wide. However, the term describes the shape of a bone, not its size, which is relative. Long bones are found in the arms (humerus, ulna, radius) and legs (femur, tibia, fibula), as well as in the fingers (metacarpals, phalanges) and toes (metatarsals, phalanges).
Hypophosphatasia (/ ˌ h aɪ p oʊ ˈ f ɒ s f eɪ t ˌ eɪ ʒ ə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP [6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]