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Benzylpenicillin, also known as penicillin G (PenG [4]) or BENPEN, [5] is an antibiotic used to treat a number of bacterial infections. [6] This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis, cellulitis, and tetanus. [6] It is not a first-line agent for pneumococcal meningitis. [6]
Penicillin G (benzylpenicillin) was first produced from a penicillium fungus that occurs in nature. The strain of fungus used today for the manufacture of penicillin G was created by genetic engineering to improve the yield in the manufacturing process. None of the other natural penicillins (F, K, N, X, O, U1 or U6) are currently in clinical use.
It is a form of penicillin which is a salt of benzylpenicillin and the local anaesthetic agent procaine. [9] The salt has weak solubility, and is prepared as a suspension. Upon injection it forms a deposit within tissue (a "depot'), and the salt slowly dissolves into interstitial fluid - dissociating the two molecules into their bioactive forms over an extended pe
Benzathine benzylpenicillin, also known as benzathine penicillin G (BPG), is an antibiotic medication useful for the treatment of a number of bacterial infections. [3] Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. [3] [5] It is also used to prevent rheumatic fever. [5] It is given by injection into a muscle.
By 1947, penicillin had been shown to be an effective cure for early syphilis and was becoming widely used to treat the disease. [100] Its use in later syphilis, however, was still unclear. [ 101 ] Study directors continued the study and did not offer the participants treatment with penicillin. [ 100 ]
For neurosyphilis, due to the poor penetration of benzathine penicillin into the central nervous system, those affected are given large doses of intravenous penicillin G for a minimum of 10 days. [ 3 ] [ 34 ] If a person is allergic to penicillin, ceftriaxone may be used or penicillin desensitization attempted. [ 3 ]
Metronidazole, Erythromycin, Procaine penicillin G: Yes: Diphyllobothrium: Diphyllobothriasis: No Dracunculus medinensis: Dracunculiasis: No Eastern equine encephalitis virus: Eastern equine encephalitis (EEE) Blood tests Corticosteroids, anticonvulsants, and supportive measures (treating symptoms) Under research [12] Ebolavirus (EBOV) Ebola ...
In early-stage syphilis drop should occur in 6–12 months; in late syphilis drop can take 12–24 months. Titers may decline more slowly in persons who have previously had syphilis. [27] In people who are allergic to penicillin, initiation of penicillin desensitization is advised.