Search results
Results from the WOW.Com Content Network
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine . It is an essential growth factor in some bacteria as well.
Spermine is synthesized from the reaction of spermidine with SAM in the presence of the enzyme spermine synthase. The polyamines undergo rapid interconversion in the polyamine cycle, in which putrescine leads to synthesis of spermidine and spermine, with degradation of these polyamines to form putrescine, which can begin the cycle again. [16]
Genetic engineering techniques allow the modification of animal and plant genomes. Techniques have been devised to insert, delete, and modify DNA at multiple levels, ranging from a specific base pair in a specific gene to entire genes. There are a number of steps that are followed before a genetically modified organism (GMO) is created.
Genetic engineering is a process that alters the genetic structure of an organism by either removing or introducing DNA, or modifying existing genetic material in situ. Unlike traditional animal and plant breeding , which involves doing multiple crosses and then selecting for the organism with the desired phenotype , genetic engineering takes ...
Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene. [5] [6] [7] Function. The product of this gene is the polyamine oxidase. This enzyme ...
Spermidine/spermine N(1)-acetyltransferase (SPD/SPM acetyltransferase) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase , spermine can be converted to spermidine and spermidine to putrescine . [ 7 ]
Spermine synthase is an enzyme involved in polyamine biosynthesis. It is present in all eukaryotes and plays a role in a variety of biological functions in plants [ 3 ] Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer formed via dimerization .
Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosylmethioninamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine. [9] SAM is required for cellular growth and ...