Search results
Results from the WOW.Com Content Network
2-Chloromethylpyridine is an organohalide that consists of a pyridine core bearing a chloromethyl group. It is one of three isomeric chloromethylpyridines, along with 3- and 4-chloromethylpyridine. It is an alkylating agent . 2-Chloromethylpyridine is a precursor to pyridine-containing ligands .
[2] The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus. Chlorine adds to the multiple bonds on alkenes and alkynes as well, giving di- or tetra-chloro compounds.
The major metabolite of MCPA degradation is MCP (4-chloro-2-methylphenol). The pathway could be the cleavage of the ether linkage, yielding MCP and acetate acid. Another pathway could be the hydroxylation of the methyl group, yielding cloxyfonac (4-Chloro-2-hydroxymethylphenoxyacetic acid). Recent studies have demonstrated that biological ...
DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride) is an organic triazine derivative commonly used for activation of carboxylic acids, particularly for amide synthesis. Amide coupling is one of the most common reactions in organic chemistry and DMTMM is one reagent used for that reaction.
The Chichibabin pyridine synthesis (/ ˈ tʃ iː tʃ iː ˌ b eɪ b iː n /) is a method for synthesizing pyridine rings. The reaction involves the condensation reaction of aldehydes , ketones , α,β-Unsaturated carbonyl compounds , or any combination of the above, with ammonia . [ 1 ]
But in 1909, K. Löffler and C. Freytag extended the transformation to simple secondary amines and applied the process in their elegant synthesis of nicotine (6) from N-bromo-N-methyl-4-(pyridin-3-yl)butan-1-amine (5). [8] [9] [10] The reaction mechanism only became clear around 1950, when S. Wawzonek investigated various N-haloamine cyclizations.
The Kröhnke method in this synthesis was crucial due to the failure of other cyclization techniques such as the Glaser coupling or Ullmann coupling. Figure 13. Another use of the Kröhnke pyridine synthesis was the generation of a number of 2,4,6-trisubstituted pyridines that were investigated as potential topoisomerase 1 inhibitors.
An illustrative example is the epoxidation of trans-2-butene with m-CPBA to give trans-2,3-epoxybutane: [4] The oxygen atom that adds across the double bond of the alkene is taken from the peroxy acid, generating a molecule of the corresponding carboxylic acid as a byproduct.