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[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first aerosol spray can. In 1933 Robert Pauli Scherer created a method to develop softgels. William Roberts studies about penicillin were continued by Alexander Fleming, who in 1928 concluded that penicillin had an antibiotic ...
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [51] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [52] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
The most widely accepted hypothesis of its action is based on the well-studied and closely related quinoline drug, chloroquine. This model involves the inhibition of hemozoin biocrystallization in the heme detoxification pathway, which facilitates the aggregation of cytotoxic heme .
Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65).
Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s)); [citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug. [1] Oral formulations (under trade name such as Endiaron [ 2 ] ) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment ...
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Several anti-malarial drugs contain quinoline substituents. These include quinine, chloroquine, amodiaquine, and primaquine. Quinoline is used as a solvent and reagent in organic synthesis. [16] Quinolinium compounds (e.g. salts) can also be used as corrosion inhibitors and intensifiers.