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HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. [ 5 ] [ 6 ] [ 7 ] It is ubiquitously expressed in many tissues and cell types. [ 8 ] The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression ...
Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. [ 4 ] Type 2 diabetes mellitus and prediabetes are associated with changes in levels of metabolic markers, these markers could serve as potential prognostic or therapeutic targets for patients with prediabetes or Type 2 ...
Individuals with type 2 diabetes who struggle to manage blood sugar levels with other treatments. People with obesity or those who have difficulty managing weight despite lifestyle changes.
Mutations in the HNF4A gene are associated with a form of diabetes called maturity onset diabetes of the young (MODY), [14] specifically MODY 1. At least 56 disease-causing mutations in this gene have been discovered. [15] Increased amplification of hepatocyte nuclear factor 4 alpha has been observed in colorectal cancer. [16]
This can increase your risk for some serious health concerns, including heart disease, type 2 diabetes, arthritis, and even certain cancers. And foods that reduce inflammation may help. And foods ...
Hepatic lipase is expressed mainly in liver cells, known as hepatocytes, and endothelial cells of the liver. The hepatic lipase can either remain attached to the liver or can unbind from the liver endothelial cells and is free to enter the body's circulation system. [ 6 ]
The typical hepatocyte is cubical with sides of 20-30 μm, (in comparison, a human hair has a diameter of 17 to 180 μm). [1] The typical volume of a hepatocyte is 3.4 x 10 −9 cm 3. [2] Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. [3]
Hepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes).