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  2. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    Conversely, food increases the area-under-curve levels of gabapentin by about 10%. [24] Drugs that increase the transit time of gabapentin in the small intestine can increase its oral bioavailability; when gabapentin was co-administered with oral morphine (which slows intestinal peristalsis), [27] the oral bioavailability of a 600 mg dose of ...

  3. Analgesic adjuvant - Wikipedia

    en.wikipedia.org/wiki/Analgesic_adjuvant

    Common anticonvulsants used to treat neuropathy are gabapentinoids (calcium channel blockers) and carbamazapine (sodium channel blocker). [8] There is some evidence that anticonvulsants may also help with inflammatory pain through reduction of nociceptor hyper-excitability originally due to damage to surrounding tissue. [9] Examples: Gabapentin ...

  4. Hereditary neuropathy with liability to pressure palsy

    en.wikipedia.org/wiki/Hereditary_neuropathy_with...

    Symptoms and symptom onset vary; some individuals are diagnosed in childhood, others in adulthood, some report minor problems, whilst others experience severe discomfort and disability. In many cases, symptoms are mild enough to go unnoticed. The time period between episodes is known to vary between individuals.

  5. Peripheral neuropathy - Wikipedia

    en.wikipedia.org/wiki/Peripheral_neuropathy

    Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).

  6. Neuropathic pain - Wikipedia

    en.wikipedia.org/wiki/Neuropathic_pain

    While some studies on orally administered ALA had suggested a reduction in both the positive symptoms of diabetic neuropathy (dysesthesia including stabbing and burning pain) as well as neuropathic deficits (paresthesia), [74] the meta-analysis showed "more conflicting data whether it improves sensory symptoms or just neuropathic deficits alone ...

  7. What is gabapentin? Here's why it's so controversial. - AOL

    www.aol.com/news/gabapentin-heres-why...

    Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...

  8. FDA takes first step to protect children from medications ...

    www.aol.com/news/fda-takes-first-step-protect...

    Children will get into anything, and children will especially get into anything that tastes or looks like candy,” said Dr. Theresa Michele, who leads the FDA’s office of nonprescription drugs.

  9. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    It is moderately effective: about 30–40% of those given gabapentin for diabetic neuropathy or postherpetic neuralgia have a meaningful benefit. [12] Gabapentin, like other gabapentinoid drugs, acts by decreasing activity of the α 2 δ-1 protein, coded by the CACNA2D1 gene, first known as an auxiliary subunit of voltage gated calcium channels.

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