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Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. [5] It is suggested to be used together with diet changes, exercise, and weight loss. [ 5 ]
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The Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 trial, also known as PROVE-IT TIMI 22, was a randomized, double-blind, clinical trial that recruited 4,162 people admitted within 10 days of an acute coronary event and randomised them to the lipid-lowering drugs pravastatin (40 mg) or atorvastatin (80 mg) and a 10-day course of the ...
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Pravastatin belongs to the group called statins. [2] It reduces total blood cholesterol by blocking the action of 3-hydroxy-3-methyl-glutaryl-coenzyme-A (HMG-CoA) reductase, an enzyme in the liver involved in the production of cholesterol. [ 2 ]
The general nature of shopping focused price comparison websites is that, since their content is provided by retail stores, content on price comparison websites is unlikely to be absolutely unique. The table style layout of a comparison website could be considered by Google as "Autogenerated Content and Roundup/Comparison Type of Pages". [ 17 ]
Pravastatin is not metabolized by CYP isoenzymes to any appreciable extent. [6] [8] [13] The statins that have the ability to be metabolized by multiple CYP isoenzymes may therefore avoid drug accumulation when one of the pathways is inhibited by co-administered drugs. [13]
These rates, which are much higher than those seen in randomized clinical trials [74] have been the topic of extensive debate and discussion. [34] [86] Muscle pain and other symptoms often cause patients to stop taking a statin. [87] This is known as statin intolerance.